A stretch of the A14 on the Suffolk-Cambridgeshire border will be closed over nights for about five months.
National Highways has announced that resurfacing works between Newmarket and Cambridge have begun and are expected to finish in the summer.
Last summer the A14 was closed between Bury St Edmunds and Newmarket as National Highways carried out repairs to the road.
Phase one of the project started on Monday, February 19 and will see the eastbound carriageway closed between junction 35 at Stow Cum Quy and junction 36 at the A11 turn-off near Newmarket.
The road will be closed on weeknights between 8pm and 5am until Friday, March 15.
Drivers will be diverted off the A14 at Stow Cum Quy onto the A1303, A1304 to join the A11 at junction 38 or to join the A14 via the B1506 at junction 39.
The second phase will begin on Monday, March 18, and will run through to the end of April.
The eastbound carriageway will be closed between junction 33 at the Milton Interchange and junction 36 at the A11 turn-off.
Drivers will be diverted off the A14 at junction 33 onto the A10 to Ely and A142 to re-join the A14 at junction 37.
Phase three will see the A14 westbound closed between junction 37 at the A11 turn-off and junction 35 at Stow Cum Quy.
The road will be closed from late April until Tuesday, May 7.
Traffic will be diverted via the A142 to Ely and A10 to re-join the A14 at junction 33.
All roadworks will be carried out on weeknights.
A spokesman for National Highways said: "The work will include resurfacing, refreshing the painted road markings, road studs and other signs.
"We'll be working for approximately five months mainly on weeknights but with some Saturday nights.
"We'll be working overnight between 8pm to either 5am or 6am, weather permitting."
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